Altered left ventricular remodeling with beta-adrenergic blockade and exercise after coronary reperfusion in rats. | Zendy

ByungHee Oh | Zendy; S Ono | Zendy; E A Gilpin | Zendy; John Ross | Zendy

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Altered left ventricular remodeling with beta-adrenergic blockade and exercise after coronary reperfusion in rats.

Author(s) -

ByungHee Oh,

S Ono,

E A Gilpin,

John Ross

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.2.608

Subject(s) - medicine , propranolol , cardiology , blockade , myocardial infarction , coronary occlusion , ventricular remodeling , perfusion , occlusion , receptor

beta-Adrenergic blockade is known to improve the survival of patients after acute myocardial infarction and to reduce myocardial infarct size in experimental coronary occlusion. However, the effects of beta-blockade on global and regional left ventricular (LV) remodeling have not been characterized after coronary occlusion with reperfusion. In rats subjected to coronary occlusion and reperfusion, we have demonstrated beneficial effects of reperfusion in sedentary rats with a hypertrophic response to exercise in the surviving outer wall of the infarcted zone, and in this study we investigated whether such remodeling is modified by beta-blockade in both sedentary and exercised rats.

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