Myocardial hypertrophy in the ischemic zone induced by exercise in rats after coronary reperfusion. | Zendy

ByungHee Oh | Zendy; S Ono | Zendy; H. A. Rockman | Zendy; John Ross | Zendy

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Myocardial hypertrophy in the ischemic zone induced by exercise in rats after coronary reperfusion.

Author(s) -

ByungHee Oh,

S Ono,

H. A. Rockman,

John Ross

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.2.598

Subject(s) - medicine , cardiology , ventricle , myocardial infarction , ventricular remodeling , perfusion , coronary occlusion , sham surgery , ischemia , occlusion , infarction , muscle hypertrophy , left coronary artery , alternative medicine , pathology

Factors influencing left ventricular (LV) remodeling after coronary artery reperfusion, including adaptive changes in the infarcted region and the role of exercise, have not been well defined. The common application of early reperfusion by thrombolysis after acute myocardial infarction lends potential significance to such remodeling, and a rat model with 45 minutes of regional ischemia followed by reperfusion was developed to study these events. We postulated that the effects of reperfusion in altering LV morphology would be further modified by exercise training, including induction of hypertrophic changes in the outer region of the nontransmural infarction.

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