Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties. | Zendy

Søren Boesgaard | Zendy; Henrik E. Poulsen | Zendy; Jan Aldershvile | Zendy; Steffen Loft | Zendy; Mary E. Anderson | Zendy; A Meister | Zendy

Open Access

Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties.

Author(s) -

Søren Boesgaard,

Henrik E. Poulsen,

Jan Aldershvile,

Steffen Loft,

Mary E. Anderson,

A Meister

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.2.547

Subject(s) - glutathione , intracellular , extracellular , buthionine sulfoximine , cysteine , in vivo , acetylcysteine , pharmacology , medicine , thiol , chemistry , endocrinology , biochemistry , antioxidant , biology , enzyme , microbiology and biotechnology

Changes in sulfhydryl (SH) compound availability may alter the hemodynamic effect of nitroglycerin (NTG). Data on the relation between NTG effect and thiol levels are, however, limited to in vitro experiments. The present study investigates how intracellular and extracellular changes in SH group concentrations (cysteine and glutathione [GSH]) affect the responsiveness to NTG in vivo.

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