Open AccessEvaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leukocyte activation.
Author(s) -
S M Shandelya,
Periannan Kuppusamy,
Myron L. Weisfeldt,
Jay L. Zweíer
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.87.2.536
Subject(s) - medicine , ischemia , granulocyte , neutrophile , complement system , inflammation , anesthesia , pharmacology , immunology , antibody
It has been hypothesized that chemotaxis and activation of polymorphonuclear leukocytes (PMNs) occur upon reperfusion of ischemic myocardium. Questions remain, however, regarding the mechanisms by which PMNs are chemotaxed and activated and how this process causes contractile failure.
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