Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs. | Zendy

Masaru Tanaka | Zendy; S E Brooks | Zendy; Vincent Richard | Zendy; G P FitzHarris | Zendy; Robert Stoler | Zendy; Robert B. Jennings | Zendy; K. E. Arfors | Zendy; K A Reimer | Zendy

Open Access

Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs.

Author(s) -

Masaru Tanaka,

S E Brooks,

Vincent Richard,

G P FitzHarris,

Robert Stoler,

Robert B. Jennings,

K. E. Arfors,

K A Reimer

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.2.526

Subject(s) - medicine , cd18 , myocardial infarction , ischemia , fissipedia , granulocyte , antibody , monoclonal antibody , carnivora , cardiology , immunology

Polymorphonuclear neutrophils (PMNs) accumulate in postischemic myocardium and may cause injury to myocardium or to vessels by production of oxygen free radicals or by release of proteases and lipases. PMN accumulation is dependent on adherence to endothelium, which is mediated by a family of glycoproteins on the PMN surface, each of which has a common beta-subunit (CD18). The purpose of this study was to determine whether an antibody (IB4) against the CD18 protein could attenuate PMN accumulation and limit myocardial infarct size.

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