Exertional fatigue due to skeletal muscle dysfunction in patients with heart failure. | Zendy

John R. Wilson | Zendy; Donna Mancini | Zendy; W. Bruce Dunkman | Zendy

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Exertional fatigue due to skeletal muscle dysfunction in patients with heart failure.

Author(s) -

John R. Wilson,

Donna Mancini,

W. Bruce Dunkman

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.2.470

Subject(s) - medicine , heart failure , skeletal muscle , cardiology , muscle fatigue , hemodynamics , blood flow , physical medicine and rehabilitation , electromyography

Exertional fatigue in patients with chronic heart failure is usually attributed to skeletal muscle underperfusion. Recently, skeletal muscle atrophy, abnormal muscle metabolic responses, and reduced muscle enzyme levels have been noted in such patients, raising the possibility that some patients may develop muscle fatigue due to intrinsic muscle abnormalities. The present study was undertaken to determine if a subpopulation of patients with heart failure develops exertional fatigue due to skeletal muscle dysfunction rather than to reduced muscle flow.

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