Open AccessImpairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics.
Author(s) -
David S. Celermajer,
S Cullen,
John Deanfield
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.87.2.440
Subject(s) - medicine , cardiology , pulmonary artery , dilator , hemodynamics , endothelial dysfunction , vasodilation , heart disease , pulmonary function testing , left pulmonary artery , acetylcholine , anesthesia
Endothelial injury may be an important event in the pathophysiology of pulmonary hypertension. We therefore investigated whether endothelial dysfunction occurs early in children with congenital heart defects who are at risk of developing pulmonary vascular disease.
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