Effect of subcutaneous sumatriptan, a selective 5HT1 agonist, on the systemic, pulmonary, and coronary circulation. | Zendy

P D. MacIntyre | Zendy; Balram Bhargava | Zendy; Karen Hogg | Zendy; J D Gemmill | Zendy; W S Hillis | Zendy

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Effect of subcutaneous sumatriptan, a selective 5HT1 agonist, on the systemic, pulmonary, and coronary circulation.

Author(s) -

P D. MacIntyre,

Balram Bhargava,

Karen Hogg,

J D Gemmill,

W S Hillis

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.2.401

Subject(s) - sumatriptan , medicine , agonist , vasoconstriction , vascular resistance , anesthesia , vasodilation , cardiology , artery , migraine , pulmonary artery , hemodynamics , receptor

Sumatriptan (GR43175) is a selective 5-hydroxytryptamine (5HT1) receptor agonist effective in the acute treatment of migraine. Recent in vitro experiments suggest that it has vasoactive properties in vascular beds distinct from the cerebral circulation. The object of this study was to assess the vasoactive effects of the standard 6-mg subcutaneous dose of sumatriptan used in migraine on the systemic and pulmonary circulations and the coronary artery vasculature.

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