Hemoglobin inhibits endothelium-dependent relaxation to acetylcholine in human coronary arteries in vivo. | Zendy

Peter Collins | Zendy; J. F. Burman | Zendy; H I Chung | Zendy; Keith A.A. Fox | Zendy

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Hemoglobin inhibits endothelium-dependent relaxation to acetylcholine in human coronary arteries in vivo.

Author(s) -

Peter Collins,

J. F. Burman,

H I Chung,

Keith A.A. Fox

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.1.80

Subject(s) - medicine , isosorbide dinitrate , vasodilation , acetylcholine , endothelium derived relaxing factor , endothelium , artery , hemoglobin , coronary arteries , cardiology , nitric oxide , anesthesia , endocrinology

The endothelium can regulate vascular tone by releasing both endothelium-derived relaxing factor (EDRF or nitric oxide) and contracting factors. To date, there has only been circumstantial evidence to indicate EDRF activity in vivo in human coronary arteries. Using human hemoglobin as a specific inhibitor, the hypothesis that acetylcholine-induced coronary vasodilation is due to EDRF release was tested.

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