Angiotensin II directly stimulates release of atrial natriuretic factor in isolated rabbit hearts. | Zendy

Amelia Focaccio | Zendy; Massimo Volpe | Zendy; Giuseppe Ambrosio | Zendy; Giuseppe Lembo | Zendy; Silvana Pannain | Zendy; Speranza Rubattu | Zendy; Iolanda Enea | Zendy; SILVANA PIGNALOSA | Zendy; M Chiariello | Zendy

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Angiotensin II directly stimulates release of atrial natriuretic factor in isolated rabbit hearts.

Author(s) -

Amelia Focaccio,

Massimo Volpe,

Giuseppe Ambrosio,

Giuseppe Lembo,

Silvana Pannain,

Speranza Rubattu,

Iolanda Enea,

SILVANA PIGNALOSA,

M Chiariello

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.1.192

Subject(s) - medicine , angiotensin ii , rabbit (cipher) , lagomorpha , renin–angiotensin system , cardiology , endocrinology , heart failure , pharmacology , receptor , blood pressure , statistics , mathematics

Previous studies have shown that infusion of angiotensin II (Ang II) increases plasma concentrations of atrial natriuretic factor (ANF) in vivo. This phenomenon has been considered secondary to the effects of Ang II on cardiac and systemic hemodynamics. The present study was designed to assess whether Ang II may exert a direct stimulatory effect on ANF release from the heart independent of changes in hemodynamics.

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