Open Access8-Methoxypsoralen and longwave ultraviolet irradiation are a novel antiproliferative combination for vascular smooth muscle.
Author(s) -
Keith L. March,
Bruce L. Patton,
R L Wilensky,
David R. Hathaway
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.87.1.184
Subject(s) - psoralen , medicine , vascular smooth muscle , trypan blue , phototoxicity , cell growth , viability assay , flow cytometry , cell cycle , biophysics , irradiation , microbiology and biotechnology , cell , endocrinology , in vitro , immunology , biology , smooth muscle , dna , biochemistry , cancer , physics , nuclear physics
Smooth muscle cell proliferation plays a major role in the genesis of restenosis after angioplasty or vascular injury. Although the effects of arterial exposure to high-energy radiation sources such as laser have been investigated in detail, the effects on vascular cells of low-intensity radiant energy in combination with photoactive agents have not been extensively characterized. Psoralens are photoactive agents that are known to be well tolerated when used in conjunction with local exposure to ultraviolet light in the A band (UVA) for the treatment of various dermatologic proliferative disorders.
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