Open AccessMyocardial uptake of 111In monoclonal antimyosin Fab in detecting doxorubicin cardiotoxicity in rats. Morphological and hemodynamic findings.
Author(s) -
Michiaki Hiroe,
Y Ohta,
Naoya Fujita,
Masashi Nagata,
Tetsuya Toyozaki,
Kiyoko Kusakabe,
M Sekiguchi,
Fumiaki Marumo
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.86.6.1965
Subject(s) - cardiotoxicity , medicine , doxorubicin , hemodynamics , diastole , cardiology , toxicity , chemotherapy , pathology , pharmacology , blood pressure
The therapeutic value of doxorubicin (DOX) is limited by its cardiotoxicity, which is dose dependent. To improve the detection of such myocardial damage, this study was designed to determine whether the 111In antimyosin antibody Fab could serve as a marker for cardiotoxicity in treated versus control rats on the basis of comparative morphological and hemodynamic findings.
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