Open AccessMyocardial protective effects of adenosine. Infarct size reduction with pretreatment and continued receptor stimulation during ischemia.
Author(s) -
Christopher F. Toombs,
Sean L. McGee,
William E. Johnston,
J. Vinten–Johansen
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.86.3.986
Subject(s) - medicine , adenosine , ischemia , cardioprotection , adenosine receptor , anesthesia , adenosine receptor antagonist , saline , adenosine a1 receptor , pharmacology , receptor , agonist
We hypothesized that 1) endogenous adenosine released during ischemia conferred an inherent cardioprotection, and 2) a pretreatment dose of adenosine before ischemia would provide additional protection independent of hemodynamic effects.
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