Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. | Zendy

David J. Lefer | Zendy; Allan M. Lefer | Zendy; Robert Rothlein | Zendy

Open Access

Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion.

Author(s) -

David J. Lefer,

Allan M. Lefer,

Robert Rothlein

Publication year - 1992

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.86.3.937

Subject(s) - medicine , intercellular adhesion molecule 1 , myocardial ischemia , monoclonal antibody , cardiology , intracellular , ischemia , adhesion , cell adhesion molecule , myocardial reperfusion injury , antibody , immunology , inflammation , microbiology and biotechnology , chemistry , organic chemistry , biology

Intercellular adhesion molecule-1 (ICAM-1) is a major ligand on endothelial cells for adherence of activated polymorphonuclear leukocytes (PMNs). The major purpose of this study was to study the effects of RR1/1, a monoclonal antibody against ICAM-1 (i.e., MAb RR1/1), on myocardial injury and endothelial dysfunction associated with myocardial ischemia and reperfusion.

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