Adenosine infusion for the reversal of pulmonary vasoconstriction in biventricular failure. A good test but a poor therapy. | Zendy

Guy A. Haywood | Zendy; James F. Sneddon | Zendy; Yaver Bashir | Zendy; Stephen H. Jennison | Zendy; H. H. Gray | Zendy; William J. McKenna | Zendy

Open Access

Adenosine infusion for the reversal of pulmonary vasoconstriction in biventricular failure. A good test but a poor therapy.

Author(s) -

Guy A. Haywood,

James F. Sneddon,

Yaver Bashir,

Stephen H. Jennison,

H. H. Gray,

William J. McKenna

Publication year - 1992

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.86.3.896

Subject(s) - medicine , vascular resistance , pulmonary wedge pressure , cardiology , cardiac index , adenosine , heart failure , pulmonary hypertension , vasodilation , anesthesia , heart transplantation , sodium nitroprusside , transplantation , hemodynamics , cardiac output , blood pressure , nitric oxide

Elevation of pulmonary vascular resistance is an important determinant of right ventricular function in patients with end-stage biventricular heart failure. Vasodilator drug therapy directed at the pulmonary vasculature is used in the hemodynamic assessment of patients for orthotopic heart transplantation, and therapy aimed at decreasing pulmonary vascular resistance and transpulmonary pressure gradient has been advocated in patients awaiting heart transplantation. Adenosine infusion has been shown to cause selective pulmonary vasodilatation in normal subjects and in patients with primary pulmonary hypertension but has not been assessed in patients with biventricular heart failure.

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