Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans. Effects of N-acetylcysteine administration. | Zendy

Stefano Ghio | Zendy; Stefano De Servi | Zendy; Rubens Perotti | Zendy; Ermanno Eleuteri | Zendy; C Montemartini | Zendy; Giorgina Specchia | Zendy

Open Access

Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans. Effects of N-acetylcysteine administration.

Author(s) -

Stefano Ghio,

Stefano De Servi,

Rubens Perotti,

Ermanno Eleuteri,

C Montemartini,

Giorgina Specchia

Publication year - 1992

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.86.3.798

Subject(s) - medicine , acetylcysteine , nitroglycerin (drug) , anesthesia , cardiology , circulation (fluid dynamics) , biochemistry , chemistry , antioxidant , physics , thermodynamics

Tolerance to the effects of organic nitrates develops rapidly during continuous exposure to these drugs; its main mechanism seems to be an intracellular sulfhydryl group depletion. However, the relative susceptibility to the development of nitroglycerin tolerance of the arterial or venous circulation in humans is still a matter of dispute.

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