Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart. | Zendy

Manuel Galiñanes | Zendy; David A. Bullough | Zendy; Kevin Mullane | Zendy; David J. Hearse | Zendy

Open Access

Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart.

Author(s) -

Manuel Galiñanes,

David A. Bullough,

Kevin Mullane,

David J. Hearse

Publication year - 1992

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.86.2.589

Subject(s) - medicine , anesthesia , ischemia , reperfusion injury , saline , cardiology

We have shown that acadesine (AICAr: 5-amino-4-imidazole carboxamide riboside) improves the early recovery of function of the ischemic and reperfused rat heart. In the present studies we used the transplanted rat heart, with reperfusion for up to 24 hours, to assess whether the beneficial effect of acadesine is a transient or a sustained phenomenon (i.e., to determine whether the drug improves the extent of recovery or only the rate).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research