Low-molecular-weight heparin reduces neointimal proliferation after coronary stent implantation in hypercholesterolemic minipigs. | Zendy

Arnd B. Buchwald | Zendy; C. Unterberg | Zendy; Klaus Nebendahl | Zendy; H.-J. Gröne | Zendy; V. Wiegand | Zendy

Open Access

Low-molecular-weight heparin reduces neointimal proliferation after coronary stent implantation in hypercholesterolemic minipigs.

Author(s) -

Arnd B. Buchwald,

C. Unterberg,

Klaus Nebendahl,

H.-J. Gröne,

V. Wiegand

Publication year - 1992

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.86.2.531

Subject(s) - medicine , restenosis , heparin , stent , artery , cardiology , angioplasty , balloon , urology , low molecular weight heparin , endothelium , angiography

Intracoronary stents have been suggested as a method of reducing the restenosis rate after balloon angioplasty. Proliferation of vascular smooth muscle cells is a major contributing factor to the restenosis process. Heparin and some of its derivatives have been shown to inhibit smooth muscle cell proliferation. We investigated the effect of low-molecular-weight heparin on the proliferative response after implantation of a balloon-expandable tantalum stent in previously deendothelialized coronary artery segments of hypercholesterolemic minipigs.

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