Effects of inhibition of nitric oxide formation on regional blood flow in experimental myocardial infarction. | Zendy

H. Drexler | Zendy; E Hablawetz | Zendy; Wenyan Lü | Zendy; U. N. Riede | Zendy; A Christes | Zendy

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Effects of inhibition of nitric oxide formation on regional blood flow in experimental myocardial infarction.

Author(s) -

H. Drexler,

E Hablawetz,

Wenyan Lü,

U. N. Riede,

A Christes

Publication year - 1992

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.86.1.255

Subject(s) - medicine , myocardial infarction , cardiology , ventricle , nitric oxide , vasoconstriction , blood pressure , infarction , vascular resistance , heart failure , omega n methylarginine , nitric oxide synthase

Large myocardial infarction is associated with reactive hypertrophy and dilation of the left ventricle, depressed coronary flow reserve, and the development of heart failure including systemic vasoconstriction. We hypothetized that changes in endothelial function, e.g., in the synthesis or action of nitric oxide in the coronary and peripheral vasculatures, might be involved in the depressed coronary flow reserve and increased systemic vascular resistance observed in postinfarction myocardial hypertrophy and failure.

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