Open AccessEffect of ketanserin on proximal and distal coronary constrictor responses to intracoronary infusion of serotonin in patients with stable angina, patients with variant angina, and control patients.
Author(s) -
E McFadden,
Christophe Bauters,
J M Lablanche,
Fabrice Leroy,
John Clarke,
M Henry,
C Schandrin,
G Davies,
A Maseri,
M Bertrand
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.86.1.187
Subject(s) - ketanserin , medicine , serotonin , constriction , angina , vasoconstriction , cardiology , occlusion , ischemia , endocrinology , anesthesia , receptor , 5 ht receptor , myocardial infarction
Serotonin, released by aggregating platelets, may contribute to or cause myocardial ischemia by constricting epicardial vessels. Experimental studies suggest that this constriction is mediated by two distinct serotonin receptor subtypes: 5-hydroxytryptamine1-like (S1-like) and 5-hydroxytryptamine2 (S2).
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