Open AccessIncreased thromboxane biosynthesis in type IIa hypercholesterolemia.
Author(s) -
Giovanni Davı̀,
Maurizio Averna,
Isabella Catalano,
Carlo M. Barbagallo,
Antonina Ganci,
A Notarbartoló,
Giovanni Ciabattoni,
Carlo Patrono
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.85.5.1792
Subject(s) - medicine , endocrinology , excretion , simvastatin , metabolite , thromboxane , thromboxane a2 , platelet , thromboxane b2 , cyclooxygenase , urinary system , enzyme , chemistry , biochemistry
Increased platelet thromboxane (TX)A2 production has been described in type IIa hypercholesterolemia. To verify the relevance of these capacity-related measurements to the actual rate of TXA2 biosynthesis in vivo, we studied the urinary excretion of its major enzymatic metabolites in 46 patients with type IIa hypercholesterolemia and 20 age-matched controls.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom