Open AccessLow level in vivo gene transfer into the arterial wall through a perforated balloon catheter.
Author(s) -
M. Y. Flugelman,
Michael T. Jaklitsch,
Kurt D. Newman,
Ward Casscells,
Gary L. Bratthauer,
David A. Dichek
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.85.3.1110
Subject(s) - in vivo , balloon catheter , medicine , restenosis , genetic enhancement , microbiology and biotechnology , catheter , gene , staining , polymerase chain reaction , artery , viral vector , pathology , biology , cardiology , surgery , recombinant dna , biochemistry , stent , genetics
Gene transfer into the arterial wall may provide a novel therapeutic strategy for the treatment of coronary artery restenosis. Previously described methods for gene transfer into the arterial wall require total vessel occlusion for 30 minutes. We sought to develop a protocol for gene transfer within a more clinically relevant time frame.
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