Platelet factor 4 efficiently reverses heparin anticoagulation in the rat without adverse effects of heparin-protamine complexes. | Zendy

Jacquelynn J. Cook | Zendy; S Niewiarowski | Zendy; Zi Yan | Zendy; L W Schaffer | Zendy; Weiqi Lu | Zendy; Gwendolyn J. Stewart | Zendy; David M. Mosser | Zendy; Jill A. Myers | Zendy; Theodore E. Maione | Zendy

Open Access

Platelet factor 4 efficiently reverses heparin anticoagulation in the rat without adverse effects of heparin-protamine complexes.

Author(s) -

Jacquelynn J. Cook,

S Niewiarowski,

Zi Yan,

L W Schaffer,

Weiqi Lu,

Gwendolyn J. Stewart,

David M. Mosser,

Jill A. Myers,

Theodore E. Maione

Publication year - 1992

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.85.3.1102

Subject(s) - medicine , heparin , protamine sulfate , platelet factor 4 , platelet , protamine , partial thromboplastin time , anesthesia , femoral vein , anticoagulant , bleeding time , pharmacology , platelet aggregation

It has been observed that the reversal of heparin anticoagulation in humans by protamine sulfate (PS) results in various adverse reactions including leukopenia, thrombocytopenia, activation of complement, increased vascular permeability, systemic hypotension, pulmonary vasoconstriction, and pulmonary edema. The purpose of this study was to compare the efficacy and effects of native platelet factor 4 (PF4) and recombinant platelet factor 4 (rPF4) with those of PS in heparin neutralization in vivo, using a rat model.

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