Effects of high arterial oxygen tension on function, blood flow distribution, and metabolism in ischemic myocardium. | Zendy

Brian A. Cason | Zendy; J A Wisneski | Zendy; Richard A. Neese | Zendy; William C. Stanley | Zendy; Robert F. Hickey | Zendy; Carla B. Shnier | Zendy; Edward W. Gertz | Zendy

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Effects of high arterial oxygen tension on function, blood flow distribution, and metabolism in ischemic myocardium.

Author(s) -

Brian A. Cason,

J A Wisneski,

Richard A. Neese,

William C. Stanley,

Robert F. Hickey,

Carla B. Shnier,

Edward W. Gertz

Publication year - 1992

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.85.2.828

Subject(s) - medicine , hyperoxia , cardiology , blood flow , ischemia , perfusion , artery , hemodynamics , anesthesia , hypoxemia , sonomicrometry , coronary circulation , lung

Although oxygen inhalation therapy has long been used in the treatment of acute myocardial ischemia, experimental evidence that increased arterial PO2 has any beneficial effect in the absence of hypoxemia is equivocal. In this study, we used a swine model of subendocardial myocardial ischemia to determine the effects of arterial hyperoxia on regional myocardial contractile function (sonomicrometry), myocardial blood flow distribution (microspheres), and regional myocardial glycolytic metabolism (carbon isotope-labeled substrates).

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