Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis. | Zendy

Marcel Levi | Zendy; Bart J. Biemond | Zendy; Anton Jan van Zonneveld | Zendy; J W ten Cate | Zendy; Hans Pannekoek | Zendy

Open Access

Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis.

Author(s) -

Marcel Levi,

Bart J. Biemond,

Anton Jan van Zonneveld,

J W ten Cate,

Hans Pannekoek

Publication year - 1992

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.85.1.305

Subject(s) - thrombolysis , thrombus , medicine , in vivo , plasminogen activator , platelet , fibrinolysis , pharmacology , plasminogen activator inhibitor 1 , monoclonal antibody , thrombosis , tissue plasminogen activator , antibody , immunology , biology , myocardial infarction , microbiology and biotechnology

We investigated the effect of inhibition of plasminogen activator inhibitor-1 (PAI-1) activity by a murine monoclonal anti-human PAI-1 antibody (MAI-12) on in vitro thrombolysis and on in vivo thrombolysis and thrombus extension in an experimental animal model for thrombosis.

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