Open AccessPreventive administration of intravenous N-acetylcysteine and development of tolerance to isosorbide dinitrate in patients with angina pectoris.
Author(s) -
Søren Boesgaard,
Jan Aldershvile,
Henrik E. Poulsen
Publication year - 1992
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.85.1.143
Subject(s) - isosorbide dinitrate , medicine , angina , placebo , crossover study , anesthesia , st segment , cardiology , myocardial infarction , alternative medicine , pathology
Development of tolerance to organic nitrates may be related to depletion of sulfhydryl groups in vascular smooth muscle. N-Acetylcysteine (NAC), a sulfhydryl donor, has been reported to potentiate the effect of nitroglycerin and reverse tolerance in humans. However, its ability to prevent or delay the development of nitrate tolerance in patients with angina pectoris has not been established.
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