Open AccessPlasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation.
Author(s) -
Muneo Yoshibayashi,
Kenya Nishioka,
Kazuwa Nakao,
Yoshihiko Saito,
Masahide Matsumura,
Tadashi Ueda,
Shinji Temma,
Gotaro Shirakami,
H Imura,
Harukí Mikawa
Publication year - 1991
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.84.6.2280
Subject(s) - medicine , pulmonary hypertension , endothelin 1 , cardiology , endothelin receptor , endothelins , pulmonary vasculature , receptor
To elucidate the pathophysiological significance of endothelin in pulmonary hypertension associated with congenital heart defects, we measured plasma endothelin-like immunoreactivity (ET-LI) concentrations by using radioimmunoassay in 18 patients with pulmonary hypertension (PH group; age, 6 months to 12 years) in comparison with 27 patients without pulmonary hypertension (non-PH group; age, 6 months to 12 years).
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