Hydrogen peroxide pretreatment of perfused canine vessels induces ICAM-1 and CD18-dependent neutrophil adherence. | Zendy

A C Gasic | Zendy; Gerald M. McGuire | Zendy; S Krater | Zendy; Anwar Farhood | Zendy; M. A. Goldstein | Zendy; C. Wayne Smith | Zendy; Mark L. Entman | Zendy; Addison A. Taylor | Zendy

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Hydrogen peroxide pretreatment of perfused canine vessels induces ICAM-1 and CD18-dependent neutrophil adherence.

Author(s) -

A C Gasic,

Gerald M. McGuire,

S Krater,

Anwar Farhood,

M. A. Goldstein,

C. Wayne Smith,

Mark L. Entman,

Addison A. Taylor

Publication year - 1991

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.84.5.2154

Subject(s) - medicine , hydrogen peroxide , endothelium , perfusion , in vivo , cd18 , neutrophile , endothelial stem cell , ex vivo , in vitro , pharmacology , immunology , inflammation , biochemistry , chemistry , flow cytometry , biology , integrin alpha m , microbiology and biotechnology

Cytotoxic products of neutrophils (polymorphonuclear leukocytes, PMNs) contribute to ischemia-reperfusion injury of several tissues. Hydrogen peroxide (H2O2), one of the cytotoxic products of PMNs, also promotes the adherence of PMNs to cultured vascular endothelial cells in vitro. The present study was undertaken to determine if H2O2 also augmented adhesion of PMNs to intact vessels perfused ex vivo and to determine if H2O2-induced PMN adherence to intact canine carotid arteries and external jugular veins or to cultured canine venous endothelium is mediated by specific adherence ligands on the neutrophil and/or the endothelium.

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