Cellular electrophysiological basis for oxygen radical-induced arrhythmias. A patch-clamp study in guinea pig ventricular myocytes. | Zendy

Elisabetta Cerbai | Zendy; Giuseppe Ambrosio | Zendy; Francesco Porciatti | Zendy; M Chiariello | Zendy; A Giotti | Zendy; Alessandro Mugelli | Zendy

Open Access

Cellular electrophysiological basis for oxygen radical-induced arrhythmias. A patch-clamp study in guinea pig ventricular myocytes.

Author(s) -

Elisabetta Cerbai,

Giuseppe Ambrosio,

Francesco Porciatti,

M Chiariello,

A Giotti,

Alessandro Mugelli

Publication year - 1991

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.84.4.1773

Subject(s) - afterdepolarization , electrophysiology , egta , medicine , patch clamp , radical , calcium , superoxide dismutase , biophysics , membrane potential , guinea pig , endocrinology , myocyte , chemistry , pharmacology , biochemistry , oxidative stress , biology , repolarization

Oxygen radicals have been implicated in the pathogenesis of reperfusion arrhythmias. However, the basic electrophysiological alterations accompanying the effects of oxygen radicals on action potential (AP) are poorly understood.

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