Thrombolytic and pharmacokinetic properties of chimeric tissue-type and urokinase-type plasminogen activators. | Zendy

D Collen | Zendy; H. R. Lu | Zendy; H.R. Lijnen | Zendy; L Nelles | Zendy; Jean Marie Stassen | Zendy

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Thrombolytic and pharmacokinetic properties of chimeric tissue-type and urokinase-type plasminogen activators.

Author(s) -

D Collen,

H. R. Lu,

H.R. Lijnen,

L Nelles,

Jean Marie Stassen

Publication year - 1991

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.84.3.1216

Subject(s) - plasminogen activator , urokinase , medicine , pharmacokinetics , potency , pharmacology , fibrin , tissue plasminogen activator , endocrinology , immunology , biochemistry , biology , in vitro

Chimeric molecules comprising the A-chain of tissue-type plasminogen activator (t-PA) and the catalytic domain of urokinase-type plasminogen activator (u-PA) have intact enzymatic characteristics of u-PA, partial fibrin-binding properties of t-PA, and thrombolytic properties in animal models comparable with but not superior to those of single-chain u-PA (scu-PA). Deletion of the finger and growth factor domains (t-PA-delta FE/scu-PA-e) in such chimeras further reduces their affinity for fibrin.

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