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The long QT syndrome. Prospective longitudinal study of 328 families.
Author(s) -
Arthur J. Moss,
Peter J. Schwartz,
Richard S. Crampton,
Dan Tzivoni,
Emanuela H. Locati,
J. W. MacCluer,
William J. Hall,
L. Weitkamp,
G. Michael Vincent,
Arthur Garson
Publication year - 1991
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.84.3.1136
Subject(s) - medicine , long qt syndrome , proband , qt interval , syncope (phonology) , cardiology , sudden death , pediatrics , sudden cardiac death , prospective cohort study , biochemistry , chemistry , mutation , gene
The Long QT Syndrome (LQTS) is an infrequently occurring familial disorder in which affected individuals have electrocardiographic QT interval prolongation and a propensity to ventricular tachyarrhythmic syncope and sudden death. We prospectively investigated the clinical characteristics and the long-term course of 3,343 individuals from 328 families in which one or more members were identified as affected with LQTS (QTc greater than 0.44 sec1/2).

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