Open AccessHemodynamic and neurohormonal effects of clonidine in patients with preganglionic and postganglionic sympathetic lesions. Evidence for a central sympatholytic action.
Author(s) -
Jaspal S. Kooner,
R. Birch,
H L Frankel,
W. S. Peart,
Christopher J. Mathias
Publication year - 1991
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.84.1.75
Subject(s) - clonidine , medicine , sympatholytic , anesthesia , blood pressure , hemodynamics , denervation , vasoconstriction , vasodilation
Clonidine, a partial presynaptic and postsynaptic alpha-adrenoceptor agonist, has been shown to lower blood pressure in normal subjects but not in tetraplegics; however, the mechanisms of this action have not been elucidated.
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