Open AccessNeutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion.
Author(s) -
William J. Dreyer,
L H Michael,
M. Stewart West,
C. Wayne Smith,
Robert Rothlein,
Roger D. Rossen,
D C Anderson,
Mark L. Entman
Publication year - 1991
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.84.1.400
Subject(s) - medicine , mechanism (biology) , cardiology , distribution (mathematics) , ischemia , mathematical analysis , philosophy , mathematics , epistemology
We have previously demonstrated that chemotactic factors released from the ischemic canine myocardium peak early during reperfusion and that they elicit neutrophil adherence reactions in vitro that are dependent on the CD18 glycoprotein family. In this study we investigated the hypothesis that neutrophil localization in ischemic canine myocardium in vivo occurs over a similar time course during early reperfusion and involves a CD18-dependent mechanism.
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