Open AccessThrombolytic therapy with streptokinase stimulates collagen breakdown.
Author(s) -
Keijo Peuhkurinen,
Leila Risteli,
Jukka Melkko,
Markku Linnaluoto,
A. J. Jounela,
Juha Risteli
Publication year - 1991
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.83.6.1969
Subject(s) - streptokinase , medicine , plasmin , myocardial infarction , creatine kinase , endocrinology , cardiology , radioimmunoassay , surgery , pharmacology , enzyme , biochemistry , biology
Plasmin is capable of degrading extracellular matrix components such as collagen in vitro. To evaluate the significance of this for in vivo conditions, we set out to study the effect of streptokinase, which acts by converting plasminogen to plasmin, on the serum concentrations of the amino-terminal propeptide of type III procollagen (PIIINP) and the carboxy-terminal propeptide of type I procollagen (PICP).
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