Release of nitrogen oxides from cultured bovine aortic endothelial cells is not impaired by calcium channel antagonists. | Zendy

Andreas Mügge | Zendy; Timothy E. Peterson | Zendy; DONNA HARRISON | Zendy

Open Access

Release of nitrogen oxides from cultured bovine aortic endothelial cells is not impaired by calcium channel antagonists.

Author(s) -

Andreas Mügge,

Timothy E. Peterson,

DONNA HARRISON

Publication year - 1991

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.83.4.1404

Subject(s) - nitric oxide , bradykinin , verapamil , calcium , calcium channel , nitric oxide synthase , extracellular , biochemistry , endothelium , endothelium derived relaxing factor , medicine , pharmacology , chemistry , receptor

The endothelium-derived relaxing factor has been shown to be nitric oxide or a related nitroso compound, synthesized by the enzyme nitric oxide synthetase, which oxidizes the guanidono nitrogens of arginine. This enzyme is activated by increases in cytosolic calcium. The effect of the clinically used calcium channel antagonists on this process is controversial. The present study was performed to determine whether calcium channel blockade with these pharmacologic agents would alter the activity of nitric acid synthetase in intact endothelial cells.

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