Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts. | Zendy

Randall E. Williams | Zendy; Jay L. Zweíer | Zendy; John T. Flaherty | Zendy

Open Access

Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts.

Author(s) -

Randall E. Williams,

Jay L. Zweíer,

John T. Flaherty

Publication year - 1991

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.83.3.1006

Subject(s) - deferoxamine , medicine , phosphocreatine , ischemia , oxygen , anesthesia , cardiology , energy metabolism , chemistry , organic chemistry

Iron may play a central role in oxygen radical generation during myocardial ischemia and after reperfusion. Because conditions during ischemia may also liberate iron, we hypothesized that administration of the iron chelator deferoxamine during ischemia would result in improved functional and metabolic recovery after postischemic reperfusion.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research