Endothelium-derived relaxing factor and coronary vasospasm. | Zendy

P. M. Vanhoutte | Zendy; Hiroaki Shimokawa | Zendy

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Endothelium-derived relaxing factor and coronary vasospasm.

Author(s) -

P. M. Vanhoutte,

Hiroaki Shimokawa

Publication year - 1989

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.80.1.1

Subject(s) - medicine , endothelium , coronary vasospasm , vasospasm , vasodilation , vasoactive , endothelium derived relaxing factor , cardiology , pathophysiology , coronary artery disease , vasoconstriction , endothelial dysfunction , basal (medicine) , myocardial infarction , coronary angiography , subarachnoid hemorrhage , insulin

The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggregating platelets are important as a source of vasoconstrictor substances. The endothelium may also produce the vasoactive substances EDHF and EDCF(s). Their pathophysiologic significance remains to be determined.

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