Heart Force Effects of Sympathomimetic Amines as a Basis for Their Use in Shock Accompanying Myocardial Infarction | Zendy

Peter C. Gazes | Zendy; Leon I. Goldberg | Zendy; Thomas D. Darby | Zendy

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Heart Force Effects of Sympathomimetic Amines as a Basis for Their Use in Shock Accompanying Myocardial Infarction

Author(s) -

Peter C. Gazes,

Leon I. Goldberg,

Thomas D. Darby

Publication year - 1953

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.8.6.883

Subject(s) - medicine , norepinephrine , myocardial infarction , shock (circulatory) , phenylephrine , cardiology , heart failure , heart rate , anesthesia , sympathomimetics , blood pressure , dopamine

The treatment of 14 patients in severe shock accompanying myocardial infarction with l-norepinephrine (Levophed) in some cases and phenylephrine (Neo-Synephrine) in others demonstrated a significantly higher recovery rate with l-norepinephrine. Twelve of the patients were in congestive heart failure. Using strain-gage technics in fully conscious, trained dogs, l-norepinephrine was shown to produce substantial increments in heart contractile force in addition to its recognized pressor effects. Approximately equipressor doses of Neo-Synephrine under the same conditions had little effect on contractile force. These pronounced differences in heart force effects are presented as a basis for the difference in clinical results.

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