Effect of Dibenzyline on Skin Temperature, Peripheral Blood Flow, and Vasomotor Responses in Normal Patients and Patients with Increased Vasoconstrictor Tone | Zendy

Marvin Moser | Zendy; Dale B. Watkins | Zendy; N. Morris | Zendy; Andrew G. Prandoni | Zendy; Thomas W. Mattingly | Zendy

Open Access

Effect of Dibenzyline on Skin Temperature, Peripheral Blood Flow, and Vasomotor Responses in Normal Patients and Patients with Increased Vasoconstrictor Tone

Author(s) -

Marvin Moser,

Dale B. Watkins,

N. Morris,

Andrew G. Prandoni,

Thomas W. Mattingly

Publication year - 1953

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.8.2.224

Subject(s) - medicine , phenoxybenzamine , vasomotor , sympathectomy , vasoconstrictor agents , peripheral , blood flow , sympatholytics , adrenergic , norepinephrine , anesthesia , vascular tone , vasoconstriction , vasodilation , propranolol , receptor , dopamine

Dibenzyline is an orally effective, moderately potent, long acting, adrenergic blocking agent. The drug is capable of at least partially preventing the vasoconstrictor responses to cold and to injected Neosynephrine. Blood flow and temperature responses to this agent do not always parallel results obtained following surgical sympathectomy, but the degree of effect appears to be sufficient to produce a clinical response. Side effects and the development of "tolerance" may limit the use of Dibenzyline in clinical medicine.

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