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Dibenzyline is an orally effective, moderately potent, long acting, adrenergic blocking agent. The drug is capable of at least partially preventing the vasoconstrictor responses to cold and to injected Neosynephrine. Blood flow and temperature responses to this agent do not always parallel results obtained following surgical sympathectomy, but the degree of effect appears to be sufficient to produce a clinical response. Side effects and the development of "tolerance" may limit the use of Dibenzyline in clinical medicine.

circulation

Effect of Dibenzyline on Skin Temperature, Peripheral Blood Flow, and Vasomotor Responses in Normal Patients and Patients with Increased Vasoconstrictor Tone