The Hemodynamic Effects of Hypotensive Drugs in Man | Zendy

Edward D. Freis | Zendy; John C. Rose | Zendy; Thomas F. Higgins | Zendy; Frank A. Finnerty | Zendy; Robert T. Kelley | Zendy; Edward A. Partenope | Zendy

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The Hemodynamic Effects of Hypotensive Drugs in Man

Author(s) -

Edward D. Freis,

John C. Rose,

Thomas F. Higgins,

Frank A. Finnerty,

Robert T. Kelley,

Edward A. Partenope

Publication year - 1953

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.8.2.199

Subject(s) - medicine , hemodynamics , splanchnic , hexamethonium , blood flow , cardiac output , cardiology , anesthesia , atropine

Further data are presented concerning the unusual hemodynamic effects of 1-hydrazinophthalazine. Previous observations demonstrating a marked increase in cardiac output in normotensive subjects are confirmed in hypertensive patients. The splanchnic vascular bed is one of the sites of increased blood flow. The similarity between the hemodynamic effects of 1-hydrazinophthalazine and pyrogens is pointed out and the pharmacologic basis for the clinically observed additive effects of 1-hydrazinophthalazine and hexamethonium is discussed.

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