Open AccessInhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men.
Author(s) -
Rainer Rauramaa,
J T Salonen,
Kari Seppänen,
Riitta Salonen,
Juha M. Venäläinen,
Merja Ihanainen,
V. Rissanen
Publication year - 1986
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.74.5.939
Subject(s) - medicine , overweight , platelet , physical exercise , cardiology , physical therapy , randomized controlled trial , intensity (physics) , population , platelet aggregation , endocrinology , body mass index , quantum mechanics , physics , environmental health
It has been postulated that platelet function plays an important role in the initiation of atherosclerosis. Currently there are no definitive data on the longer-term effects of regular physical exercise on platelet function in humans. We assessed the influence of regular moderate-intensity physical exercise (brisk walking to slow jogging) on platelet aggregation in a population-based sample of middle-aged, overweight, mildly hypertensive men in eastern Finland. In this controlled study, we evaluated the net effect of exercise on platelet aggregation by studying changes in optical density and ATP release in platelet-rich plasma. A significant inhibition of secondary platelet aggregation from 27% to 36% was observed in the men taking regular exercise. These findings give new insight into the possible protective effects of exercise against the risk of ischemic heart disease.
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