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Tritium-labeled cholesterol has been fed to a selected series of patients to demonstrate a quantitative metabolic defect in lipid metabolism in the presence of abnormal serum lipoprotein spectra. Patients with abnormal serum lipoprotein spectra carry a greater fraction of their newly absorbed cholesterol in the esterified form than do normals.

A Quantitative Metabolic Defect in Lipid Metabolism Associated with Abnormal Serum Lipoproteins in Man