Phenolic Compounds in the Treatment of Rheumatic Fever | Zendy

Norman E. Clarke | Zendy; Robert E. Mosher | Zendy

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Phenolic Compounds in the Treatment of Rheumatic Fever

Author(s) -

Norman E. Clarke,

Robert E. Mosher

Publication year - 1953

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.7.3.337

Subject(s) - gentisic acid , medicine , hydroquinone , confusion , excretion , homogentisic acid , pharmacology , biochemistry , chemistry , psychology , psychoanalysis , salicylic acid

The absorption and excretion of gentisic acid has been studied to help clarify the confusion that exists in the literature. Data are given that support the retarding action of methyl cellulose and Benemid and also the manner in which these compounds are metabolized in the human body. The first metabolic study of the ethanolamide of gentisic acid in human subjects is described. Evidence is presented that the antirheumatic property of certain phenolic compounds may be explained by the phenomena of chelation and the possible existence of a reversible hydroquinone-quinone system in the blood stream.

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