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Patients with severe essential hypertension have been carefully studied periodically in an attempt to group them as to probable life expectancy. Forty such patients have been observed while on oral 1-hydrazinophthalazine and a low salt diet. Nineteen of the 33 patients in the groups having a relatively good prognosis for survival had some decrease in diastolic pressure. Only one of seven patients in Smithwick group IV had a satisfactory reduction in blood pressure.

1-Hydrazinophthalazine (Apresoline in the) reatment of Hypertension: A Two Year Study