Pneumonitis and pulmonary fibrosis associated with amiodarone treatment: a possible complication of a new antiarrhythmic drug. | Zendy

Samuel M. Sobol | Zendy; Louis Rakita | Zendy

Open Access

Pneumonitis and pulmonary fibrosis associated with amiodarone treatment: a possible complication of a new antiarrhythmic drug.

Author(s) -

Samuel M. Sobol,

Louis Rakita

Publication year - 1982

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.65.4.819

Subject(s) - medicine , amiodarone , pulmonary fibrosis , complication , pneumonitis , lung biopsy , interstitial pneumonitis , fibrosis , pulmonary toxicity , cardiology , cardiac decompensation , lung , decompensation , hypersensitivity pneumonitis , anesthesia , respiratory disease , heart failure , atrial fibrillation

Six patients are presented who developed pulmonary infiltrates of undetermined origin while being treated for severe ventricular arrhythmias with amiodarone hydrochloride. Biopsy material was available in four patients and revealed interstitial or alveolar fibrosis and pneumonitis. Four patients recovered and two died of severe cardiopulmonary decompensation; all of the patients who recovered received corticosteroid therapy. Pulmonary fibrosis is a previously unreported complication of amiodarone therapy.

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