Radionuclide imaging of experimental myocarditis. | Zendy

William C. Reeves | Zendy; Graham Jackson | Zendy; Fred W. Flickinger | Zendy; H G Kwee | Zendy; E J Schwiter | Zendy; Jacob Werner | Zendy; L Whitesell | Zendy; M A Biddle | Zendy; G. L. Copenhaver | Zendy; B S Shaikh | Zendy; R. Zelis | Zendy

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Radionuclide imaging of experimental myocarditis.

Author(s) -

William C. Reeves,

Graham Jackson,

Fred W. Flickinger,

H G Kwee,

E J Schwiter,

Jacob Werner,

L Whitesell,

M A Biddle,

G. L. Copenhaver,

B S Shaikh,

R. Zelis

Publication year - 1981

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.63.3.640

Subject(s) - medicine , myocarditis , precordial examination , nuclear medicine , radionuclide imaging , cardiac imaging , isotopes of technetium , technetium 99 , pathology , cardiology , radiology , electrocardiography

The ability of 67Ga citrate and 99mTc pyrophosphate cardiac imaging to detect myocarditis was assessed in an experimental rabbit model. Twenty-three rabbits were imaged approximately 72 hours after infusion of i.v. norepinephrine. Diffuse cardiac uptake was found in 13 of 15 rabbits scanned with 67Ga. Tissue distribution studies documented significant myocardial uptake of 67Ga in those with positive scans. Precordial imaging and tissue distribution studies revealed no cardiac uptake in the eight rabbits scanned with 99mTc. Histologic examination of all 23 hearts revealed qualitatively similar, typical lesions of myocarditis. This study suggests that cardiac imaging with 67Ga may be useful in the detection of myocarditis.

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