Circulating platelet products in unstable angina pectoris. | Zendy

M Sobel | Zendy; E W Salzman | Zendy; G C Davies | Zendy; Robert I. Handin | Zendy; Jon Sweeney | Zendy; Jeannette Ploetz | Zendy; G Kurland | Zendy

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Circulating platelet products in unstable angina pectoris.

Author(s) -

M Sobel,

E W Salzman,

G C Davies,

Robert I. Handin,

Jon Sweeney,

Jeannette Ploetz,

G Kurland

Publication year - 1981

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.63.2.300

Subject(s) - medicine , unstable angina , platelet , platelet factor 4 , beta thromboglobulin , cardiology , radioimmunoassay , thromboxane b2 , angina , coagulation , platelet activation , arachidonic acid , thromboxane a2 , endocrinology , coronary heart disease , myocardial infarction , biochemistry , chemistry , enzyme

In 19 patients with unstable angina pectoris at rest, plasma levels of the platelet-derived proteins beta-thromboglobulin and platelet factor 4 were significantly elevated in blood samples obtained during or within 4 hours after episodes of angina, but were usually normal during quiescent intervals. Plasma levels of the arachidonic acid metabolite thromboxane B2 were less clearly related to angina, and there was no association of angina with levels of the coagulation product fibrinopeptide A. This demonstration of an association of platelet activation and secretion with unstable angina pectoris by radioimmunoassay of circulating platelet constituents offers a new approach to assessment of therapy in ischemic heart disease and suggests that agents that alter platelet function should be evaluated in patients with unstable angina.

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