Open AccessThe angiographic effect of ergonovine and nifedipine in coronary artery spasm.
Author(s) -
Sushama Rich,
Lincoln E. Ford,
Jafar AlSadir
Publication year - 1980
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.62.5.1127
Subject(s) - ergonovine , medicine , nifedipine , cardiology , ergometrine , provocation test , angina , artery , coronary vasospasm , vasoconstriction , anesthesia , calcium channel blocker , calcium , myocardial infarction , alternative medicine , pathology
In a patient with variant angina, we have shown that the calcium-channel blocker nifedipine inhibits both spontaneous and ergonivine-induced coronary artery spasm. It had no effect, however, on the dose-related diffuse vasoconstriction caused by ergonovine, suggesting two distinct responses of coronary arteries to ergonovine provocation. Nifedipine did not cause epicardial coronary artery dilatation, as did nitroglycerin, supporting the rationale of using both therapies together to treat coronary artery spasm.
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