Open AccessA Comparative Evaluation of Tromexan and Dicumarol in the Treatment of Thromboembolic Conditions—Based on Experience with 514 Patients
Author(s) -
Louis A. Scarrone,
Dorothy Fahs Beck,
Irving S. Wright
Publication year - 1952
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.6.4.489
Subject(s) - medicine , anticoagulant therapy , myocardial infarction , surgery , cardiology
An evaluation of the comparative actions of Tromexan and dicumarol is herein reported. Five hundred fourteen patients were studied; a total experience of 6,642 days of Tromexan therapy and 5,006 days of dicumarol therapy were reviewed and analyzed. Previous reports of the more rapid initial prolongation of the prothrombin times and more rapid return to normal following cessation of therapy with Tromexan were confirmed. During adequate therapy the protection against thromboembolism was approximately equal for the two drugs. In other respects and with minor variations Tromexan and dicumarol were found to be quite comparable. The general advantages of anticoagulant therapy in the prevention of deaths and thromboembolic complications in myocardial infarction were comfirmed.