Graded Reduction of Arterial Pressure in Man by Means of a Thiophanium Derivative (Ro 2-2222) | Zendy

Stanley J. Sarnoff | Zendy; Walter T. Goodale | Zendy; L. CHARLOTTE SARNOFF | Zendy

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Graded Reduction of Arterial Pressure in Man by Means of a Thiophanium Derivative (Ro 2-2222)

Author(s) -

Stanley J. Sarnoff,

Walter T. Goodale,

L. CHARLOTTE SARNOFF

Publication year - 1952

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.6.1.63

Subject(s) - medicine , tachyphylaxis , ephedrine , anesthesia , vasodilation , peripheral , blood pressure , cardiology , pharmacology

The authors describe the use of a ganglionic blocking agent which acts almost entirely as a peripheral vasodilator with minimal side effects in man. This substance acts almost instantaneously when given intravenously, with the depressor effect quantitatively controlled by regulating the infusion rate without tachyphylaxis over several hours. Depressor effect of the drug disappears 2 to 15 minutes after stopping the infusion and is blocked promptly by intravenous ephedrine, neosynephrine or norepinephrine. The authors discuss its use in the treatment and elucidation of the basic mechanisms of acute pulmonary edema.

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